Maria Pennuto Selected Research

X-Linked Bulbo-Spinal Atrophy

7/2022	Editorial Comment to Castration-resistant prostate cancer diagnosed during leuprorelin treatment for spinal and bulbar muscular atrophy.
3/2021	ClC-2-like Chloride Current Alterations in a Cell Model of Spinal and Bulbar Muscular Atrophy, a Polyglutamine Disease.
1/2021	Clenbuterol-sensitive delayed outward potassium currents in a cell model of spinal and bulbar muscular atrophy.
1/2021	Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity.
10/2020	Disease mechanism, biomarker and therapeutics for spinal and bulbar muscular atrophy (SBMA).
1/2020	Polyglutamine-Expanded Androgen Receptor Alteration of Skeletal Muscle Homeostasis and Myonuclear Aggregation Are Affected by Sex, Age and Muscle Metabolism.
1/2020	MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.
1/2019	Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy.
1/2018	From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet?
10/2017	Altered ionic currents and amelioration by IGF-1 and PACAP in motoneuron-derived cells modelling SBMA.

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Maria Pennuto Research Topics

Disease

27	X-Linked Bulbo-Spinal Atrophy 07/2022 - 07/2007
13	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 07/2007
7	Atrophy 01/2022 - 12/2012
7	Neuromuscular Diseases (Neuromuscular Disease) 01/2022 - 07/2013
5	Muscular Atrophy (Muscle Atrophy) 01/2022 - 01/2016
5	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2021 - 01/2009
4	Disease Progression 10/2021 - 03/2016
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020 - 01/2013
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 01/2009
2	Hypertrophy 01/2022 - 01/2017
2	Muscle Weakness 01/2022 - 10/2020
2	Parkinson Disease (Parkinson's Disease) 01/2021 - 09/2015
2	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 09/2015
2	Huntington Disease (Huntington's Disease) 01/2021 - 03/2016
2	Hypoxia (Hypoxemia) 01/2020 - 01/2020
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 10/2017 - 03/2016
2	Nervous System Diseases (Neurological Disorders) 01/2017 - 07/2013
1	Prostatic Neoplasms (Prostate Cancer) 07/2022
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/2021
1	Tremor (Tremors) 10/2020
1	Prodromal Symptoms 10/2020
1	Neoplasms (Cancer) 01/2020
1	Carcinogenesis 01/2020
1	Necrosis 01/2020
1	Body Weight (Weight, Body) 01/2020
1	Fasciculation (Fasciculations) 01/2018
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 03/2016
1	Gynecomastia 12/2012
1	Neuroblastoma 09/2012
1	Congenital central hypoventilation syndrome 09/2012
1	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 07/2012
1	Proteostasis Deficiencies 08/2010
1	Demyelinating Diseases (Demyelinating Disease) 02/2006

Drug/Important Bio-Agent (IBA)

30	polyglutamineIBA 01/2022 - 07/2007
24	Androgen Receptors (Androgen Receptor)IBA 03/2021 - 07/2007
8	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2012
5	AndrogensIBA 01/2016 - 10/2011
3	Peptides (Polypeptides)IBA 01/2021 - 12/2016
3	Insulin-Like Growth Factor I (IGF-1)IBA 01/2020 - 08/2009
3	Mutant Proteins (Protein, Mutant)IBA 01/2018 - 02/2006
2	ClenbuterolIBA 01/2021 - 01/2017
2	Protein Isoforms (Isoforms)IBA 01/2021 - 12/2012
2	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 01/2021 - 01/2018
2	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2021 - 01/2015
2	Ligases (Synthetase)IBA 01/2020 - 01/2020
2	UbiquitinIBA 01/2020 - 01/2020
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2020 - 09/2012
2	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2018 - 12/2016
2	Glutamine (L-Glutamine)FDA Link 03/2016 - 01/2016
1	Leuprolide (Lupron)FDA LinkGeneric 07/2022
1	ChromatinIBA 01/2022
1	Prion ProteinsIBA 12/2021
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 12/2021
1	Cyclophilin AIBA 10/2021
1	ChloridesIBA 03/2021
1	NeuropeptidesIBA 01/2021
1	PotassiumIBA 01/2021
1	Arginine (L-Arginine)FDA Link 01/2021
1	Ion Channels (Ion Channel)IBA 01/2021
1	CreatinineIBA 10/2020
1	Biomarkers (Surrogate Marker)IBA 10/2020
1	MEF2 Transcription FactorsIBA 01/2020
1	Hypoxia-Inducible Factor 1IBA 01/2020
1	Transforming Growth Factor beta (TGF-beta)IBA 10/2019
1	TransglutaminasesIBA 10/2017
1	geldanamycinIBA 01/2015
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2015
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2015
1	Mitochondrial DNA (mtDNA)IBA 01/2015
1	CaspasesIBA 01/2015
1	UbiquinoneIBA 01/2015
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2015
1	Pioglitazone (Actos)FDA Link 01/2015
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2015
1	idebenoneIBA 01/2015
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2012
1	polyalanineIBA 09/2012
1	Myelin P0 Protein (Myelin Protein Zero)IBA 07/2012

Therapy/Procedure

4	Therapeutics 10/2020 - 07/2013
1	Castration 07/2022
1	Denervation 01/2022
1	Muscle Denervation 01/2020